JS Graphics JS Graphics JS Canvas JS Plotly JS Chart.js JS Google Chart JS D3. JS vs jQuery jQuery Selectors jQuery HTML jQuery CSS jQuery DOM JS JSON JSON Intro JSON Syntax JSON vs XML JSON Data Types JSON Parse JSON Stringify JSON Objects JSON Arrays JSON Server JSON PHP JSON HTML JSON JSONP JS AJAX AJAX Intro AJAX XMLHttp AJAX Request AJAX Response AJAX XML File AJAX PHP AJAX ASP AJAX Database AJAX Applications AJAX Examples JS Web APIs Web API Intro Web Forms API Web History API Web Storage API Web Worker API Web Fetch API Web Geolocation API JS Browser BOM JS Window JS Screen JS Location JS History JS Navigator JS Popup Alert JS Timing JS Cookies JS HTML DOM DOM Intro DOM Methods DOM Document DOM Elements DOM HTML DOM Forms DOM CSS DOM Animations DOM Events DOM Event Listener DOM Navigation DOM Nodes DOM Collections DOM Node Lists JS Async JS Callbacks JS Asynchronous JS Promises JS Async/Await JS Classes Class Intro Class Inheritance Class Static The tDate() method is used to set date of a month into a date object which are created using date() constructor. JS Functions Function Definitions Function Parameters Function Invocation Function Call Function Apply Function Bind Function Closures JS Objects Object Definitions Object Properties Object Methods Object Display Object Accessors Object Constructors Object Prototypes Object Iterables Object Sets Object Maps Object Reference If the dayValue is outside of the range of date values for the month, setDate() will update the Date object. The number of milliseconds between 1 January 1970 00:00:00 UTC and the given date (the Date object is also changed in place). JavaScript dateObj </ var >.setDate(dayValue </ var >) Parameters dayValue An integer representing the day of the month. setDate (dayValue) Parameters dayValue An integer representing the day of the month.So, summarizing, you can create a new Date object in 4 ways. JS Versions JS Versions JS 2009 (ES5) JS 2015 (ES6) JS 2016 JS 2017 JS 2018 JS IE / Edge JS History () The setDate() method sets the day of the Date object relative to the beginning of the currently set month. JavaScript, without any information about the timezone, will consider the date as UTC, and will automatically perform a conversion to the current computer timezone. addDays ( 7 ) ) // T00:00:00.JS Tutorial JS HOME JS Introduction JS Where To JS Output JS Statements JS Syntax JS Comments JS Variables JS Let JS Const JS Operators JS Arithmetic JS Assignment JS Data Types JS Functions JS Objects JS Events JS Strings JS String Methods JS String Search JS String Templates JS Numbers JS Number Methods JS Arrays JS Array Methods JS Array Sort JS Array Iteration JS Array Const JS Dates JS Date Formats JS Date Get Methods JS Date Set Methods JS Math JS Random JS Booleans JS Comparisons JS If Else JS Switch JS Loop For JS Loop For In JS Loop For Of JS Loop While JS Break JS Iterables JS Sets JS Maps JS Typeof JS Type Conversion JS Bitwise JS RegExp JS Errors JS Scope JS Hoisting JS Strict Mode JS this Keyword JS Arrow Function JS Classes JS Modules JS JSON JS Debugging JS Style Guide JS Best Practices JS Mistakes JS Performance JS Reserved Words addDays = function ( days ) // Add 7 Days const date = new Date ( '' ) Ĭonsole. In the first field, if the date is set, then in the second date time field, the date. var currentDate new Date () tHours (currentDate.getHours ()+5) ('field').setValue (currentDate) Hi, I have two date time fields. You could even add a new method to the Date's prototype and call it directly whenever you want to manipulate days like below: Date. with JavaScript you can get only the client datetime, not the server one. To update the existing JavaScript Date object, you can do the following: const date = new Date ( ) ĭate. The following example demonstrates how you can add a day to the new instance of JavaScript Date object: const today = new Date ( ) const tomorrow = new Date ( ) // Add 1 Day These methods are used to set and get the day of the month of the Date object. To add days to a date in JavaScript, you can use the setDate() and getDate() methods of the Date object.
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A specialist will often want advanced imaging, such as the MRI, completed prior to the appointment. Referral to a spine specialist, such as a neurosurgeon, is also recommended if symptoms persist for greater than four weeks.Radiographic imaging, such as an MRI, is not recommended by the American College of Radiology, unless symptoms have been present for six weeks.Primary care evaluation during this time may lead to considering other non-surgical treatments noted below, such as physical therapy.Walking as tolerated is encouraged, along with an anti-inflammatory, such as ibuprofen, if not contraindicated for the patient. The time to improve varies, ranging from a few days to a few weeks. With time, the symptoms of sciatica/radiculopathy improve in approximately 9 out of 10 people. The pain may increase with certain positions or movements of the neck.įortunately, the majority of herniated discs do not require surgery. Along with leg pain, one may experience low back pain however, for acute sciatica the pain in the leg is often worse than the pain in the low back.Ĭervical spine (neck): Cervical radiculopathy is the symptoms of nerve compression in the neck, which may include dull or sharp pain in the neck or between the shoulder blades, pain that radiates down the arm to the hand or fingers or numbness or tingling in the shoulder or arm. Straightening the leg on the affected side can often make the pain worse. It may be more severe with standing, walking or sitting. This pain often is described as sharp and electric shock-like. Usually, one side (left or right) is affected. Pressure on one or several nerves that contribute to the sciatic nerve can cause pain, burning, tingling and numbness that radiates from the buttock into the leg and sometimes into the foot. Lumbar spine (lower back): Sciatica/Radiculopathy frequently results from a herniated disc in the lower back. Typically, a herniated disc is preceded by an episode of low back pain or a long history of intermittent episodes of low back pain. If it is pressing on a nerve, there may be pain, numbness or weakness in the area of the body to which the nerve travels. If the herniated disc is not pressing on a nerve, the patient may experience a low backache or no pain at all. Symptoms vary greatly, depending on the position of the herniated disc and the size of the herniation. The area in which pain is experienced depends on what part of the spine is affected. Herniated discs are more common in the lower back (lumbar spine), but also occur in the neck (cervical spine). Herniated discs can occur in any part of the spine. Due to this displacement, the disc presses on spinal nerves, often producing pain, which may be severe. The spinal canal has limited space, which is inadequate for the spinal nerve and the displaced herniated disc fragment. Discs that become herniated usually are in an early stage of degeneration. Located between each of the vertebra in the spinal column, discs act as shock absorbers for the spinal bones.Ī herniated disc (also called bulged, slipped or ruptured) is a fragment of the disc nucleus that is pushed out of the annulus, into the spinal canal through a tear or rupture in the annulus. These discs are round, like small pillows, with a tough, outer layer (annulus) that surrounds the nucleus. The bones (vertebrae) that form the spine in the back are cushioned by discs. Herniated Disc | American Association of Neurological Surgeons “Is that… no… it can’t be… no, no, no FUCKING way! They actually did it, they added Larry David, the crazy bastards!” one Twitch streamer screamed during a live broadcast of the trailer, in which Larry David stepped out of the shadows as the Curb Your Enthusiasm theme music begins to play. We’re very excited, especially, for Larry’s special moves, which include things like disrespecting wood, staring people down in the face, and having sex with beautiful women several decades younger than him.”įollowing the reveal, many gamers expressed excitement and glee across the internet, some even recording their live reactions. David’s unique moveset of sarcastic one-liners, shrugs, and swooping hand gestures. Soon, you’ll be able to defeat Tom and Jerry, Batman, and Steven Universe using Mr. “Ever since the announcement of MultiVersus, fans have been practically begging for Larry David’s inclusion to the roster. “We here at Player First Games want to do right by fans of the original properties our characters come from,” director Tony Huynh said during a recent Warner Brothers Direct. Interactive Entertainment, in collaboration with developer Player First Games, announced the first round of DLC characters for their fighting game MultiVersus, starting with the first addition to the roster, comedian Larry David from the HBO comedy series Curb Your Enthusiasm. Bob Barr is a research scientist with IUPUI’s Center for Earth and Environmental Sciences.LOS ANGELES - Warner Bros. Larry Clemens is state director of The Nature Conservancy’s Indiana Chapter. Our elected officials need to hear at every opportunity how important wetlands are to all Hoosiers. To do this, we need to make sure reasonable regulations remain in place to guide decision-making and boost funding for the Clean Water Indiana fund to $5 million a year. Hoosiers can keep fighting the good fight and urge their lawmakers to help our wetlands continue to provide their important functions. Members heard from Hoosiers who care about clean water and good habitats when they attempted to abolish all regulations in 2021. Indiana’s wetlands are too important to be overlooked in the Indiana General Assembly. Read more: Op-Ed: Indiana needs to spend more on water infrastructure or risk dirty drinking water The restoration work at Ritchey Woods shows what can be done but much more is needed.īut, do you know what’s even better than a restored wetland? A natural one. Without question, wetlands are a natural resource that we cannot afford to lose, especially in the face of more severe weather events brought on by climate change. Wetlands are a natural infrastructure to help reduce flooding, which saves residents and their insurance companies millions in losses. During severe rainstorms, which are becoming the norm in Indiana, millions of gallons of water that would otherwise add to flooding in the White River and nearby neighborhoods are held in the wetlands at Ritchey Woods. Hare Creek runs through Ritchey Woods and into Cheeney Creek, which then flows into the White River. Read more: Op-Ed: Indiana is cleaning up its waterways and proactively preventing contamination That’s enough water to fill 44 basements in average sized homes with a foot of water! According to Purdue University, just 1 acre of isolated wetland 1 foot deep can hold 330,000 gallons of water that otherwise would flood surrounding areas. When it comes to flooding, wetlands can store massive amounts of water that otherwise would worsen flooding downstream. Without wetlands, it costs more for communities to treat their drinking water. Those services include water purification and storage and erosion prevention. Just 1 acre of wetlands, which is less than the size of a football field, provides more than $3,500 in benefits to Hoosiers each year. Wetlands provide real financial benefits too, according to the Indiana Department of Natural Resources. Wetlands restored by Ray McCormick on Thursday, May 20, 2021, on or near Vincennes land owned by McCormick, a conservationist who's opposed to a recently passed law that will strip many wetlands protections away to make room for Hoosier developers. Users can also proceed directly to the analysis using the recommended defaults. Highlighting may be included in the print reports as well.įigure 9: GeneMarker allows for easy customization of analysis settings. These probes will also be displayed as triangles in the ratio plot. JPEG formats.įigure 8: Highlighting helps draw attention to probes of particular interest. Reports may be printed directly, or electronically saved in. If the Quality Control Fragments do not pass, a failed message will be shown in red font on the final report. They can be customized to display the entire sample, a particular peak, or clusters of peaksįigure 7: When the Automated Quality Control Settings are used, the final report will denote whether the Quality Control Fragments passed or failed. This setting can be turned on/off under View Preferences.ĭetailed Reports Ensure Results are Communicated Clearly and Effectivelyįigure 6: Reports include an informative header, electropherogram, ratio plot, validation box, and report table. Saturated and Saturated/Repaired peaks are not recommended for any quantitative calculations and will result in a pop-up warning message.Īdditional Quality Warnings for Analysts moving to Post-genotyping Applicationsįigure 5: If there are flagged alleles present in one or more of the samples, the program will warn the user when attempting to access a Post-genotyping Application before the flags are resolved. The detected peak will be given the Quality Reason, SD, and a red underscore at the corresponding location on the electropherogram. These settings help make quality control easier and more rigorous.Īutomated Detection and Repair of Saturated Peaksįigure 4: Saturation Detection (SD) will detect saturated peaks. The program will alert the user if one or more of the Quality Control Settings are turned off (as shown in Figure 3).įigure 3: The program automatically detects important quality control fragments within each sample, and alerts the user if the behavior of any fragment is outside of the norms recommended by MRC Holland. Both methods improve the linearity of the data, allowing more accurate and consistent results.Īutomated Quality Control Increases Rigor and Efficiencyįigure 2: The Quality Control Settings are automatically turned on when the MLPA template is selected. Control Probe Normalization uses the internal control probes to normalize peak heights (recommended by MRC Holland for most chemistries) whereas Population Normalization uses all probes in a sample to normalize peak heights (recommended for chemistries that do not have internal control probes throughout the main marker for the kit. MLPA Normalization Increases the Accuracy and Consistency of Analysisįigure 1: GeneMarker software gives users two methods of data normalization. (In this example there is one heterozygous deletion, and seven homozygous duplications.)įigures 1 – 11 provide details on the MLPA analysis workflow in GeneMarker software. The resulting peak ratios are plotted in the ratio plot below, and are reported for each sample in the Report Table to the right. >The trace comparison (top, middle) shows a direct comparison between the selected sample and the reference. GeneMarker software’s MLPA analysis screen comparing test samples (blue trace) to normal controls (red trace). Interested in Next Generation sequence analysis for MLPA? Click here information on analysis of MLPA data from Next Generation platforms such as Illumina or Ion Torrent and Download the application note NextGENe Batch CNV - MLPA Replacement ( PDF) Analysts can access MLPA panels through GeneMarker software's panel editor, our website, or GeneMarker software's MLPA application has been validated by research hospitals worldwide, is included in EuroGentest validation report, and is an excellent alternative to GeneMapper® and Coffalyser.Net Software. GeneMarker software is compatible with outputs from all major sequencing systems, including ABI®PRISM, Applied Biosystems® SeqStudio™, and Promega Spectrum Compact genetic analyzers, as well as custom primers or commercially available chemistries. MLPA analysis with GeneMarker software is both rapid and accurate, allowing complete MLPA or MS-MLPA analysis of 96 samples in just minutes. The MLPA analysis application is linked directly to the program, allowing the user to process raw data, normalize samples, and perform MLPA analysis all in one program, eliminating unnecessary data transfers. GeneMarker software provides an entire module dedicated to MLPA analysis in-house, no internet needed. Kits are commercially available through MRC Holland. Multiplex Ligation-dependent Probe Amplification (MLPA) is a rapid, high-throughput technique for detecting copy number changes, with both general and clinical research applications. MLPA® (Multiplex Ligation-dependent Probe Amplification) Analysis to detect and report copy number variations using GeneMarker Software Teorex iResizer with Serial Keydownload from the links given below.
Check out some safety tips below from the Utah Poison Control Center (UPCC) to keep your family and your pets safe as you de-winterize your home and properties. The City will be divided into East and West sections using the CSX Railroad Tracks as the dividing line during the two (2) weeks clean up. 12:30 PM Spring Cleaning Tips Spring has sprung and that means many people are beginning their spring cleaning. “WHOLE TREES WILL NOT BE ACCEPTED.” One (1) truckload per household will be strictly enforced. There will be a limit of 6 tires per resident. Residents are advised to keep white goods (stoves, refrigerators, etc.) & tires separated from other disposed of articles. The Daily Mail and Keep Britain Tidy are teaming up for another year to safely bring. Tyler Essary / TODAY Illustration / Getty Images. During Easter 2019, this item was obtainable from Marliinas Homestore within the Designer Boutique. The Clean Up does not include commercial or contractors who have debris. Join The Great British Spring Clean 2021 for a Greener Britain. Six expert-approved tips that will kickstart your spring cleaning. The Spring Cleaning Headband is an accessory available from the Easter 2019 and Easter 2021 Egg Hunt events. The City will only pick up articles placed at the resident’s property line (either at the front roadway or at the alleyway). This week, Emily guides us through seven simple tasks thatll take your home from winter hibernation den to a clean spring oasis for you and your loved ones. You don’t get anything clean without getting something else dirty. 2021 Spring Clean-up Day 2 (April 27): Briarwood Finwood Tanglewood Dogwood Day 4 (April 29): Ashford East Shannon West Shannon Day 5 (April 30): Stout W. My idea of superwoman is someone who scrubs her own floors. PLEASE NOTE: If your items are not out on your designated cleanup day we will not be able to return due to time restrictions. The following motivational spring cleaning quotes are on the humorous side. Your spring clean-up items will be picked up on your regular refuse collection day. Please note that Friday, June 18th is a recognized holiday so your Spring Clean-Up items will be collected on Thursday, June 17, 2021. Covington City residents will have the opportunity to dispose of unwanted items through the City’s Spring Clean-up to be held the weeks of June 7, 2021, through June 17, 2021. The standard cyan, magenta, and yellow cartridges cost $10 each and last for 300 pages (3.3 cents per page), while the standard black costs $12 and lasts for 250 pages, or 4.8 cents per page (cpp). Ink costs for the Photosmart 7520 are about average for a mainstream inkjet. Even draft-setting documents, which issue forth considerably faster, are more than legible. Text is sharp and dark at default settings, and nearly laser-like at best settings. Monochrome graphics lacked a distracting green or purple tinge. Photos, printed using a high-quality setting, feature an elegantly cool color palette and excellent detail in even dark areas. The Photosmart 7520’s output quality is among the best we’ve seen from an inkjet. Scanning and copying speeds are a tad faster than average compared with other inkjet MFPs we’ve tested. A letter-size, high-resolution photo printed on the Mac to glossy paper took about 2.5 minutes (a middling rate of 0.4 ppm). The same photo on letter-size photo paper took 62 seconds (0.98 ppm). A 4-by-6-inch photo printed at default settings on plain (letter-size) paper took about 16 seconds (or 3.75 ppm). We chose a higher-quality setting for printing color photos, producing slower times but better output quality (see below). Monochrome pages of text and text with graphics emerged at 9.5 pages per minute (ppm) on the PC and 9 ppm on the Mac. The unit achieved average to better speeds in our tests. The Photosmart can print and scan in duplex (both sides of the page), but duplex scanning requires two passes. However, the lid for the A4 flatbed scanner doesn’t telescope to accommodate thicker materials. There’s also a 25-sheet automatic document feeder (ADF) for the scanner. The main paper tray holds 125 sheets, and integrated into its top is a secondary photo tray that holds up to 20 sheets of photo paper (5-by-7-inch maximum). While the Photosmart 7520 is photo-centric, its paper-handling features extend well beyond that. 251)." Still, Hoyle argues that there must have been some "intelligence" behind the emergence of life on Earth. To forestall any speculation about his apparent "conversion," he says bluntly: "I am not a Christian, nor am I likely to become one as far as I can tell (p. 11-12).ĭoes this mean that Hoyle has become a creationist? Well, not exactly, and he doesn't expect to either. …as biochemists discover more and more about the awesome complexity of life, it is apparent that its chances of originating by accident are so minute that they can be completely ruled out. In his well-illustrated and impressive new book, The Intelligent Universe (London: Michael Joseph, 1983, 256 pp.), Hoyle says: And still another is Hoyle's own proposal, a remarkable mutation of neo-Darwinism. Another idea, a less popular one, is Jean Piaget's recommendation to reinstate the long rejected Lamarckism-the view that learned or acquired traits might be passed on from one generation to the next. Stephen Jay Gould has proposed reviving the despised view of Goldschmidt who believed in "hopeful monsters," the idea that something like a dog, say, might just hatch from, say, a chicken's egg once in a great while. Now that evolutionists admit openly that the fossil record never did support the neo-Darwinian orthodoxy after all, they need a substitute. His reasoning slams like a steel door against any kind of accidental evolution, and several have recently been proposed in one form or another to plug the holes in neo-Darwinism-especially the gaps in the fossil record. It couldn't just happen without intelligence. Darwinism is the game and Sir Fred Hoyle (1915-present), the distinguished astronomer, is the odds maker. No, not poker, and not Edmond Hoyle (1672-1769), the famed authority on card games and chess. The player may also be constrained by pre-set objects that may help or hinder their assembly line construction and cannot be removed. The player's view is from a first-person perspective and can be freely moved about the puzzle's landscape, including vertically by using a jetpack. This construction process is similar to other block-building games like Minecraft, though there are no limits on the number of blocks that can be placed. The player has an unlimited amount of time to set up the various components that make up the assembly line, including conveyor belts, welders to attach pieces to each other, and sensors to trigger devices like pushers. Within each puzzle, the player is tasked to deliver a number of objects, constructed from one or more types of cube, to one or more delivery points by directing and assembling the individual cubes from their spawning point. Additional chapters have since been added during the game's time in Early Access, adding in new block types and furthering the story of the abductees' escape attempts. By successfully completing all the puzzles, the player's character is rescued from the alien race by other abductees to a hidden base on the alien homeworld, and begins to work with the other abductees to find a way to escape the planet and return home. Completing a specified quota of puzzles on a world lets the player advance to the next one, as well as advancing the story. The game is divided into 6 worlds with several puzzles per world. The player takes the role of a human that is abducted by an alien race and is put to work to help the aliens construct equipment the character does not appear to be the first one that has been taken for this purpose as throughout the levels are the corpses of other abducted humans, which the player can find and listen to their last audio log. Infinifactory is a puzzle game, structured as several sets of puzzles based on various tasks. Its cannon shot is a mine that stays in place until an enemy touches it or it is shot. If the Slug Digger is destroyed, the player is killed. The players cannot get out of the Slug, neither can they perform the Metal Slug attack with it. It has retractable drills on the left, right, and bottom sides, which are used to drill into the earth, and sports two vulcan cannons, which can also be used to drill through things by firing bullets into the dirt. A multi-purpose subterranean digger as well as a helicopter. Later on in the level, the Donkey Slug acquires a two-wheeled out-house cart mounted with a Metal Slug cannon that replaces the player's grenade with Metal Slug cannon shots. Like all Animal Slugs, the donkey provides no protection to the rider. Roba Slug: A donkey with a mounted vulcan cannon. The Metal Slug, Type-R Metal Slug, Slug Flyer and a Slug Gunner prototype make an appearance in the game, as well as some new ones. When all 4 missions are completed on Easy mode, the game says "To be continued", meaning that the game must be played on Hard mode to continue with the final mission and see the ending. He can perform his "Super Argentine Backbreaker" against most non-vehicle enemies using it on a vulnerable target grants him temporary invincibility during and after the move, while earning generous amounts of points that increase with each additional enemy thrown. Clark: Gets an extra chance at start of respawn.Lastly, he is the only character able to damage vehicles and larger enemies with his melee attacks. Additionally, he can take two hits from most attacks before losing a life. He can also use the special "Galactica Phantom" attack. Ralf: Melee attack speed is doubled, at the expense of weapon and grenade supplies being halved.When throwing, she can aim in a specific direction. Eri: Receives twice as many grenades upon starting or resupplying.Fio: Begins each mission with the Heavy Machine Gun (on Easy mode, she begins with the Big Heavy Machine Gun from Metal Slug X and 3).He also is capable of using Vulcan Fix when on or in any vehicle. Tarma: While riding in or on a Slug, durability and the effects of power-ups are doubled additionally, the vulcan cannon's power is increased by 50%. Marco: His default weapon (Pistol on Hard, Heavy Machine Gun on Easy) has twice the ordinary strength.The amount of ammunition received from weapons, defensive ability of vehicles, and running speed vary from person to person, each of whom possess a special ability: The number of playable characters has expanded for the first time since Metal Slug 2 the original team of Marco Rossi, Tarma Roving, Eri Kasamoto and Fio Germi is joined by newcomers Ralf Jones and Clark Still of King of Fighters and Ikari Warriors fame.Īs a series first, each playable character now possesses his or her own unique attributes. When it says "Max" enemies and destructible objects will drop coins for an extra high score. The faster the speed at which enemies are killed, the higher the power, as a meter at the bottom of the screen shows. The score is now multiplied by powers of 2. When obtaining a new weapon power-up, it will automatically occupy the inactive slot, or, if both are holstered, replace the less recent weapon of the two. Players can switch between the two weapons, or simply put them both away in favor of the default weapon. Two gun power-ups can now be carried at the same time. Metal Slug 6 introduces a new play mechanic dubbed the 'Weapon Stock System'. Conversely, the sliding technique from Metal Slug 5 has been removed, and players except Fio and Ralf only receive half as much ammo for special guns. A secondary melee attack is also available. Characters can now throw away one gun power-up's worth of ammunition, to give to the other player or simply discard altogether. New techniques are now present, activated through certain button combinations. Easy mode lowers the difficulty of the game and changes the player's default weapon to the Heavy Machine Gun however, the game ends just before the fifth and final mission.Īs with previous installments, Metal Slug 6 adds a number of new Slugs as well as a new weapon, the Zantetsu Sword, which allows the player's melee weapon to emit lethal energy waves that can neutralize enemy firepower. There are now two modes of play the player can choose from right at the beginning: Easy and Hard. Rather than repeating the previous games' events of the Martians breaking the alliance and the Rebels assisting the player in turn, the player now teams up with the Rebels and Martians to combat an even greater threat. Metal Slug 6 returns to the Rebel-Martian alliance featured in Metal Slugs 2, X, and 3, but on a much broader scale. |
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